Clinical Physiology: Increased Metabolic Turnover Rate and Transcapillary Escape Rate of Albumin in Long-Term Juvenile Diabetics

Parving, H.-H., Rossing, N. & Sander, E. Increased Metabolic Turnover Rate and Transcapillary Escape Rate of Albumin in Long-Term Juvenile Diabetics. Scand. J. din. Lab. Invest. 35, 59–66, 1975.The metabolic turnover rate and transcapillary escape rate of albumin were studied with 131I-labelled human albumin in nine patients with long-term diabetes mellitus. Retinopathy was present in all patients and nephropathy in four. Plasma albumin concentration and plasma volume were reduced (P < 0.05). The previously reported decrease in the intravascular albumin mass in long-term diabetics was thus confirmed by an average of 59.0 g/m2 surface area, compared with a normal value of 71.7 g/m2 (-18yo) (P < 0.005). The albumin metabolic rate was increased, the fractional disappearance rate being an average 13.2yo of the intravascular albumin mass per 24 hr, compared with a normal value of 8.4% (+ 57%) (P < 0.001). The rate of synthesis was 7.7 g. 24 h−1. m-2 in contrast to a normal rate of 6.2 g. 24 h-1. m-2 (+24%) (P ...