Research progress of zebrafish used in drug metabolism

Zebrafish is widely used as a model organism in the process of drug discovery.It expresses drug metabolizing enzymes like cytochrome P450(CYP450),uridine 5'-diphospho-glucuronosyltransferase(UGT) and nuclear receptors like pregnane X receptor(PXR),aryl hydrocarbon receptor(AHR),etc.This article summarized the profiles of main drug metabolizing enzymes and nuclear receptors,and reviewed the advances on xenobiotics metabolism in zebrafish.