Process for manufacturing pharmaceutical multiparticulates.

A method of forming multiparticulates, comprising providing a drug in crystalline form that includes a volatile species having a vapor pressure of at least 1 KPa) at an operating temperature T followed by the following steps: (a) forming a molten mixture that comprising said drug and a carrier at said temperature T; (B) forming droplets from said molten mixture; and (c) freezing said droplets into a freezing medium to form multiparticulates comprising said drug and said carrier wherein said volatile species is added during at least one of steps (a), (b) and (c).