Ruthenium Oxidase Catalysis for Site‐Selective C–H Alkenylations with Ambient O2 as the Sole Oxidant

Ruthenium(II) oxidase catalysis by direct dioxygen-coupled turnover enabled step-economical oxidative CH alkenylation reactions at ambient pressure. Versatile ruthenium(II) biscarboxylate catalysts displayed ample substrate scope and proved applicable to weakly coordinating and removable directing groups. The twofold CH functionalization strategy was characterized by exceedingly mild reaction conditions as well as excellent positional selectivity.