Comparative studies of constant ocular potential and dark adaptation in patients taking glycerol ascorbate

: Examination of ocular constant potentials and darkness adaptation in the patients taking glycerol ascorbate has revealed that this hypotensive agent depressed the constant potentials in normal subjects, this manifesting by a drastic reduction of its darkness and light reaction. Simultaneous studies of darkness adaptation have shown it to be but slightly elevated or unchanged. The authors suppose that hyperosmotic stress induced by glycerol ascorbate involves the pigmented epithelium, a constant potential generator.