Esters of Bicyclic Aminoalcohols II*: The Synthesis of the Hydroxyquinolizidines and Some of Their Esters as Potential Therapeutic Agents

Synthesis of esters of 1- and 3-hydroxyquinolizidine as well as of the parent aminoalcohols is described, and preliminary screening suggests that antispasmodic activity is enhanced by the beta -arrangement. Suitable esters of all three aminoalcohols have also been synthesized to determine the degree of local anesthetic activity associated with them. A significant degree of inhibition of spontaneous motor activity in rats was noted with the trimethoxybenzoates of 1- and 3-hydroxyquinolizidine.