Reply to “Comment on “Free-Radical Formation by the Peroxidase-like Catalytic Activity of MFe2O4 (M = Fe, Ni and Mn) Nanoparticules.””

Recently we have reported a qualitative, quantitative and reproducible study of the generation of free radicals as a result of the surface catalytic activity of Fe3O4, Fe2O3, MnFe2O4 and NiFe2O4 nanoparticles as a function of the Fe2+/Fe3+ oxidation state under different pHs (4.8 and 7.4) and temperatures (25 ○C and 40 ○C) condition. These results were contrasted with those obtained from the in vitro experiments in BV2 cells incubated with dextran-coated magnetic nanoparticles. Based on these results we affirm that our ferrite magnetic nanoparticles catalyze the formation of free radicals and the decomposition of H2O2 by a ‘peroxidase-like’ activity. B. In a comment on this article, Meunier and A. Robert question two points: First they assert that the measured free radicals are not produced by a peroxidase reaction. Also, based on a different normalization method from those reported in our work, they also discuss that the reaction is not catalytic. Here we reply the arguments of the authors about these tw...