A Unique Case of Chronic Myeloid Leukemia Occurring in an Adolescent Male

Background: Patients with chronic myeloid leukemia (CML) usually present in elderly age and rarely in the adolescents and young adults (AYA) population. There is a limited understanding of disease management and survival outcomes in this group of patients. Case Presentation: An 18-year-old man presents to our hospital for abdominal pain and weight loss. Examination pertinent for splenomegaly and labs significant for profoundly elevated white cells count. FISH was positive for BCR/ABL1 fusion gene, and thus, he was diagnosed with CML and treated with TKI with clinical improvement. Conclusion: Tailoring CML novel therapeutic strategies in the AYA population to different disease characteristics will better advance our understanding of this disease in this patient population.