Pulmonary regulation of fibrinogen levels in acquired heart defects with pulmonary hypertension

: Fibrinogen levels and aortic and pulmonary-artery blood pressure were measured in 143 patients with acquired heart diseases and pulmonary hypertension and in 60 control patients. The lungs were shown to participate in the regulation of fibrinogen levels both in the controls and patients with heart diseases, as reflected in the deposition-balance-mobilization phases by positive, zero, negative arterio-venous difference of fibrinogen levels. The association between the metabolic and hemodynamic functions of the lungs is particularly obvious, if pressure gradients (pulmonary-capillary and bronchial perfusion ones), making for blood inflow into the alveolar-capillary region, are examined.