Pediatric Urology Copeptin as a Novel Biomarker in Nocturnal Enuresis

Copeptin levels were significantly lower in patient group (3.74 � 1.44 pg/mL) than the control group (16.57 � 3.91 pg/mL), whereas AVP levels were not significantly different between groups. Copeptin levels were significantly lower in patients (3.17 � 1.15 pg/mL) who had bed-wetting 2 or more nights a week, which is considered as severe bed-wetting, than the patients (4.95 � 1.24 pg/mL) who had bed-wetting 1 night or less than 1 night a week. CONCLUSION This study demonstrates the presence of decreased levels of copeptin in patients with NE compared with healthy patients. AVP levels were not different between groups. To our knowledge, this is the first report assessing the relationship between copeptin and NE. UROLOGY 82: 1120e1124, 2013. � 2013 Elsevier Inc.