АНАЛИЗ ГОРМОНАЛЬНЫХ ИЗМЕНЕНИЙ, ВЛИЯЮЩИХ НА УСКОРЕНИЕ ТЕМПОВ СТАРЕНИЯ УЧАСТНИКОВ ЛИКВИДАЦИИ ПОСЛЕДСТВИЙ АВАРИИ НА ЧЕРНОБЫЛЬСКОЙ АЭС ЧЕРЕЗ 18 И 28 ЛЕТ

Clinical and laboratory indicators of the neuroendocrine system were analyzed along with the phenomenon of premature aging and androgen status in 68 male liquidators of the accident at the Chernobyl nuclear power plant aged (48.0 ± 1.2) 18 years after the accident and 56 liquidators aged (67.2 ± 8.8) 28 years after the accident with a fixed radiation dose from 20 to 125 cGy as per accounting cards. Biological age was defined via the method of the Institute of Gerontology, Academy of Medical Sciences of the USSR, based on clinical and instrumental examinations. The control group consisted of 19 men without history of radiation exposure and other occupational hazards. According to assessments, subgroups with the biological age of 60 years and over 60 years were identified. By passport age, these subgroups did not differ significantly. With increasing biological age and index of premature aging, hormonal imbalance (decreased testosterone, free androgen index, prolactin, DHEAS, increased cortisol, disrupted negative feedback) typical for physiologic were revealed in Chernobyl cleanup workers. In 28 years after the accident, these changes became more pronounced.