Intradermal vaccination for Mycoplasma hyopneumoniae

Results: Injection site reactions were minimal for all vaccines. Pigs vaccinated ID, either by needle or needleless injector, had significantly higher M hyopneumoniae antibody titers than did pigs vaccinated by IM injection. Pigs vaccinated by needleless ID injection had lower lung lesion scores and higher IgA and IgG titers in bronchoalveolar lavage fluid than did nonvaccinates following challenge. Protective immunity was established by 21 days postvaccination after a single ID dose of vaccine. Intradermal vaccination of swine for M hyopneumoniae by needleless injector was safe and efficacious, and did not require shaving or other preparation of the skin.