Solubilization of Fluasterone in cosolvent/cyclodextrin combinations

Abstract The combined effect of cosolvent (methanol (MeOH), ethanol (EtOH), or n -propanol ( n -PrOH)) and complexant hydroxypropyl-β-cyclodextrin (HPβCD) on the solubility of Fluasterone is evaluated and explained with a simple equation. The calculated constants in the equation not only quantitatively describe the dependence of drug solubility on cosolvent and ligand concentrations, but also explain the minima that are observed in the Fluasterone solubility versus cosolvent concentration curves at fixed HPβCD concentrations.