Antileishmanial Activity of a New 8‐Hydroxyquinoline Derivative Designed 7‐[5′‐(3′‐Phenylisoxazolino)methyl]‐8‐hydroxyquinoline: Preliminary Study.
2004
Abstract 7-[5′-(3′-phenylisoxazolino)methyl]-8-hydroxyquinoline a new synthetic 8-hydroxyquinoline derivative, was found, for the first time, to inhibit the multiplication in vitro of Leishmania tropica, Leishmania major and Leishmania infantum at micromolar concentrations. For each test we calculated a 50% inhibitory concentration (IC 50 ) and the IC 50 values found after 48 h are: 0.4 μg/ml for L. tropica , 0.88 μg/ml for L. major and 0.62 μg/ml for L. infantum . As positive control, amphotericin B, a standard antileishmanial drug was used.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
1
References
0
Citations
NaN
KQI