Determination of retinal nerve fibre layer (RNFL) and ganglion cell/inner plexiform layers progression rates using two optical coherence tomography systems - the PROGRESSA study.
2020
IMPORTANCE Glaucoma progression rates may differ depending on the retinal structural parameters measured and between devices. BACKGROUND To compare retinal nerve fibre layer (RNFL) and ganglion cell/inner plexiform layers (GCL/IPL) progression rates using two spectral-domain optical coherence tomography (OCT) systems. DESIGN Prospective, university hospital setting. PARTICIPANTS Cross-sectional study: 100 eyes from 53 glaucoma suspects and early manifest glaucoma cases. Longitudinal study: subset of 61 eyes from 33 participants. METHODS Same day optic nerve and macular images were acquired using Cirrus and Spectralis systems from which RNFL and GCL/IPL thicknesses were calculated. Longitudinal analysis of RNFL and GCL/IPL progression rates was calculated from 6x6- monthly follow-up OCT scans. MAIN OUTCOME MEASURES RNFL and GCL/IPL thicknesses in matched superior, inferior, and global regions were compared by both systems cross-sectionally and longitudinally. RESULTS At baseline, no RNFL thicknesses differed between devices. Cirrus GCL/IPL regions were significantly thicker than Spectralis (p<0.001). RNFL and GCL/IPL global progression rates (μm/yr) had a mean (SD) of -1.28 (1.11) and 95% CI:[-1.48, -1.09], and -0.51 (0.58) and 95% CI:[-0.62, -0.41], respectively. Progression rates were similar across devices. RNFL loss (%) progressed significantly faster than GCL/IPL, in all regions (p≤0.004). CONCLUSION Despite baseline thickness differences, overall Cirrus and Spectralis provided similar rates of RNFL and GCL/IPL progression in early glaucoma and can be considered comparable, though not interchangeable, in clinical practice. Further analysis is needed to determine if RNFL progresses faster than GCL/IPL in glaucoma, and whether one precedes the other. This article is protected by copyright. All rights reserved.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
47
References
2
Citations
NaN
KQI