Serum contents of IL-23 and IL-17 in the patients with ulcerative colitis and the clinical significance.

AIM:To study the serum contents of IL-23 and IL-17 in the patients with ulcerative colitis and the clinical significance.METHODS:40 patients with ulcerative colitis as UC group and 30 healthy people as control group were selected.The serum contents of IL-23 and IL-17 were determined bll ELISA.RESULTS:Serum contents of IL-23 and IL-17 in UC group were higher than those in control group significantly(t=18.76,21.48,P0.01).Serum contents of IL-23 and IL-17 increased with the clinical symptoms.Serum contents of IL-23 and IL-17 in severe patients were higher than those of mild and moderate patients significantly,and serum contents of IL-23 and IL-17 in mild patients were higher than those of moderate patients significantly.Serum contents of IL-23 were positively correlated to IL-17 significantly(r=0.548,P0.01).CONCLUSION:IL-23 and IL-17 participates in the pathogenesis of ulcerative colitis.IL-23 may play a critical role in the development of UC through inducing production of IL-17.