Angiogenic and Arteriogenic Factors: Their Role in the Treatment of Cancer and Arterial Regeneration

Angiogenesis is modulated by hypoxia and is concerned with the development of capillaries, whereas arteriogenesis is regulated by fluid shear stress and is concerned with the formation of arteries from arterioles. It is hoped that treatment of cancer will emerge with the development of agents based on knowledge concerning cancer genome in addition to antiangiogenic therapy. On the other hand, novel approaches based on molecular mechanisms for fluid shear stress as well as the development of new growth factors are needed for the therapy of cardiovascular diseases.