93 SERUM DICKKOPF-1 (DKK-1) LEVELS ARE INCREASED IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS, BUT DECREASED IN PATIENTS WITH KNEE OSTEOARTHRITIS AND ARE ASSOCIATED WITH CARTILAGE AND SYNOVIAL TISSUE TURNOVER

significant correlation has been observed between radiological damage index and COMP levels, with a Pearson correlation index of 0.45 (95%CI: 0.32−0.64, p = 0.018). Conclusions: We observed increased serum COMP levels in patients with symptomatic radiological hand OA. Higher serum COMP levels seems to correlate to more aggressive and severe disease, in terms of pain (VAS values) and radiologic damage (Kellgren and Lawrence index).