Composite lymphomas - diagnosis and evolution

meet the criteria required for being classified as such (1). Due to the fact that the diagnosis of such rarely encountered lympho-proliferative entities has recently increased and to the huge progresses in molecular biology and immunological histological chemistry, monitoring and treating such pathology has became quite a challenge. We selected two cases of composite lymphomas hospitalized in our clinic in 2005, and we further describe the case particularities with focus to their diagnosis, evolution and therapeutic options. T he composite lymphomas are defined as two different subtypes of clone proliferation, unrelated neither morphologically nor genetically, but which occur in the same anatomical region. First, the diagnosis was performed using merely morphological criteria, but starting with the use of molecular biology and immunological – histological chemistry techniques it became obvious that many of the so-called “composite lymphomas” no longer