Formulation and Evaluation of SMEDDS with Capmul MCM for Enhanced Dissolution Rate of Valsartan

The present investigation was carried to develop self microemulsifying drug delivery system (SMEDDS) for solubility enhancement of water insoluble drug (Valsartan).Based on the pseudo ternary phase diagrams five formulations (SM1, SM2, SM3, SM4, and SM5) were prepared and evaluated for dispersibility, robustness on dilution, percentage of transmittance, viscosity, globule size analysis, zeta potential, scanning electron microscopy and in-vitro dissolution studies. The results revealed that the formulation SM4 (28.8% w/w-Capmul MCM, 44.8% w/w- Cremophor RH 40, 22.4% w/w -1, 2- propylene glycol) considered as the optimized formula because of its globule size, zeta potential and in vitro release of 98.28% within 40 min. Also scanning electron microscopy indicated that self microemulsifying drug delivery system after converting to micro emulsion showed an elongated oil droplet size of around 100 nm.The zeta potential indicated that the formation of micro emulsion depended dramatically on concentration of COO − groups for oils which decrease the surface charge of the emulsions. The studies demonstrated the promising use of SMEDDS for the delivery of Valsartan by the oral route with improved solubility and dissolution rate.