Synthesis, Radiolabeling, and In Vivo Pharmacokinetic Evaluation of the Amyloid Beta Radioligand [11C]AZD4694 in Nonhuman Primates

Purpose [18F]AZD4694 (2-(2-18F-fluoro-6-(methylamino)-3-pyridyl)benzofuran-5-ol) is a radioligand suitable for imaging of amyloid beta deposits in the living human brain using positron emission tomography (PET). Here, we report the preparation and pharmacokinetic profile of its carbon-11 (t 1/2 = 20.4 min) labeled isotopolog [11C]AZD4694 and compare [11C]AZD4694 with the hitherto most widely applied amyloid PET radioligand [11C]Pittsburgh Compound B (PiB).