Genetic variations in the matrix metalloproteinase‐1 promoter and risk of susceptibility and/or severity of chronic periodontitis in the Czech population

Matrix metalloproteinase-1 (MMP-1) is a potent enzyme degrading extracellular matrix, which was implicated in the pathogenesis of chronic periodontitis. Therefore, the aim of our study was to examine the association between three promoter polymorphisms of the MMP-1 gene and chronic periodontitis susceptibility and/or severity in a Czech population.