Enantioselective Diynylation of Cyclic N‐Acyl Ketimines: Access to Chiral Trifluoromethylated Tertiary Carbinamines.

A novel enantioselective diynylation of cyclic N-acyl trifluoromethylketimines with chloramphenicol-amine derivatives as chiral additives has been successfully developed. A series of diynylated tertiary trifluoromethylcarbinamines were obtained in high yields with good to excellent enantioselectivities (with up to 99% ee).