Nephropathy associated with Gardner-Diamond syndrome. Autologous erythrocyte antigen-antibody immune-complex disease.

In 1955 Gardner and Diamond1 described four women in whom purpura, erythema, edema and painful ecchymoses developed either spontaneously or at sites of minimal trauma on the trunk and extremities. Extensive studies of standard hemtologic and coagulation indexes revealed no characteristic abnormalities. Skin tests suggested that an etiopathogenic factor was present in the red-cell stroma.1 This paper reports etiologic and immunopathogenic studies of the renal lesion in a patient with glomerulonephritis associated with the Gardner-Diamond or autoerythrocyte-sensitization syndrome. Case Report and Methods A 20-year-old woman was admitted to an affiliated hospital of the University of Colorado Medical Center for evaluation . . .