Absolute configuration of a rare dibenzoylmethane derivative from Dahlstedtia glaziovii (Fabaceae)

Abstract Dibenzoylmethanes (DBMs) belong to a small group of flavonoids, known as β-hydroxychalcones, rarely found in nature. Despite their biological and chemotaxonomic importance, the absolute configuration of C-8 substituted DBMs has never been reported. Herein, the absolute stereochemistry of 2′-methoxy-8-(α-α-dimethylallyl)-[3′,4′:4″,5″]-furan-dibenzoylmethane is determined using the VCD exciton chirality method, which may be safely applied to other members of this class.