SYNTHESIS OF N-(3-CYANO-7-ETHOXY-1,4-DIHYDRO-4-OXOQUINOLIN-6-YL)ACETAMIDE

Compound (VIII) (overall yield: 31% over 10 steps) is an important key intermediate for the synthesis of EKB-569 or neratinib which are dual irreversible inhibitors of the epitermal growth factor receptor.