NEW THIOUREIDES OF 2-THIOPHENEACETIC ACID WITH POTENTIAL PHARMACOLOGICAL ACTIVITY. NOTE 2.

In this paper we present the synthesis of new thioureides from 2-thiopheneacetic acid performed by the addition of various primary aromatic amines to the 2-thienyl isothiocyanate. The best reaction conditions in order to obtain with good yields high pure compounds were established. The chemical structure and the purity of the new compounds were confirmed by 1 H-NMR and 13 C-NMR spectra. The obtained substances were tested by qualitative and quantitative methods on various microbial and fungal strains. Rezumat In această lucrare prezentăm sinteza unor noi tioureide ale acidului 2-tiofenacetic obţinute in urma adiţiei diferitelor amine aromatice primare la isotiocianatul de 2-tienil. Au fost stabilite condiţiile optime de reacţie cu scopul de a obţine compusi puri si cu randamente cât mai mari. Structura chimică si puritatea noilor compusi a fost confirmată prin spectrometrie 1 H-RMN si 13 C-RMN. Compusii obţinuţi au fost testaţi prin metode