Total body-surface area as a new prognostic variable in mycosis fungoides and Sézary syndrome
2016
AbstractMycosis fungoides and Sezary syndrome (MF/SS) are the most common forms of primary cutaneous T cell lymphomas. We analyzed the applicability of the cutaneous lymphoma international prognostic index (CLIPi) in MF/SS. We introduced the total body-surface area affected (TBSA) and the type of skin lesions at diagnosis as prognostic variables. The overall survival (OS) at median time of follow up (96 months) was 75.6% (CI 95%, 62.0–98.5%). In the univariate analysis, age >60 years, advanced disease, type of skin lesions and TBSA >50 showed poorer OS (p 60 years, with advanced disease and TBSA >50% (p < 0.05). TBSA identified a group of poor prognosis patients with advanced MF/SS that may benefit from novel systemic therapies.
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