Synthetic Studies of a Didemnin B Analog Based on a 2,3‐Diamino Sugar Scaffolding

Reductive amination, amide formation using BOP [(1H-1,2,3-benzotriazol-1-yloxy)tris(dimethylamino)-phosphonium hexafluorophosphate] and esterification via DCC (dicyclohexylcarbodiimide) were the key synthetic steps to generate an advanced intermediate in the preparation of a didemnin B analog based on a sugar scaffolding (2). This analog should provide insight into the bioactive conformation of didemnin B.