THE CHANGE IN ACUTE PHASE PROTEIN AS SELF-DEFESE MECHANISM IN DIABETIC PATIENT AFTER ABDOMINAL OPERATION

Acute phase protein, which are produced after operation or various insulants, play an important role as a self-defense mechanism of the body. It can be supposed that diabetic patients after surgery may differ from non-diabetic patients in the production of acute phase proteins in the liver, because of their severe postoperative catabolic condition and not an uncommon presence of latent liver dysfunction.In this study we compared for post-operative changes in acute phase reactants (CRP, α1-antitripsin, haptoglobin, α1-acid glycoprotein, fibronectine, complement) between 6 daibetic and 24 non-diabetic patients, who were operated on for tumorous leisions in the stomach and colon. Diabetic patients differed from non-diabetic in the protease inhibitor, such as α1-antitrypsin, pancreatic trypsin-inhibitor, and α1-acid glycoprotein, complement C3. It is assumed that these differences are related to the unsat isfactory repairing faculty and the high infectivity of diabetic patients. And the abnomality of acute phase protein and surgical complications will be reduced if diabetes are appropriately managed before operation.