One-Pot Synthesis of 3-Alkoxy-2,3-dihydro-1H-isoindol-1-ones by the Reactions of 2-(Azidomethyl)benzoates with NaH.
2015
A new and facile method for the general preparation of 3-alkoxy-2,3-dihydro-1H-isoindol-1-ones has been developed. Thus, the reaction of 2-(azidomethyl)benzoates with NaH affords, after workup with H2O, 3-alkoxy-2,3-dihydro-1H-isoindol-1-ones 2. 2-Substituted 3-alkoxy-2,3-dihydro-1H-isoindol-1-ones 4 can be obtained by adding alkyl halides prior to workup with H2O.
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