Increased fetuin-B levels are associated with carotid intima media thickness and hormonal-metabolic disturbances in women with polycystic ovary syndrome

Objective: Fetuin-B is a novel peptide hormone involves in energy metabolism, atherosclerosis and reproductive system. Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disorder associated with increased cardiovascular risk factors. We aimed to ascertain whether circulating fetuin-B levels were altered in women with PCOS and whether there was any association between fetuin-B and hormonal-metabolic parameters as well as carotid intima media thickness (CIMT). Material and Methods: Eighty women with PCOS and 80 age- and BMI-matched controls without PCOS were recruited to this cross-sectional study. Circulating fetuin-B levels were measured by ELISA. Metabolic- hormonal parameters and CIMT of recruited subjects were also determined. Results: Circulating fetuin-B levels were significantly elevated in women with PCOS compared to controls (409.54 ± 32.51 vs. 325.53 ± 26.86 ng/ml, P<0.001). PCOS subjects with insulin resistance showed significantly elevated circulating fetuin-B levels compared to those PCOS subjects without insulin resistance (416.03 ± 30.41 vs. 399.27 ± 33.56 ng/ml, P = 0.024). Overweight/obese women had significantly higher circulating fetuin-B levels than lean subjects in PCOS groups (416.32 ± 30.99 vs. 400.82 ± 32.77 ng/ml, P = 0.033). Fetuin-B levels positively correlated with BMI, homeostasis model assessment of insulin resistance (HOMA-IR), free-androgen index (FAI), high sensitivity C-reactive protein (hs-CRP), triglycerides and CIMT in PCOS subjects whereas fetuin-B negatively correlated with high density lipoprotein cholesterol (HDL-C). Moreover, binary logistic regression analysis revealed that the risk of having PCOS was increased in parallel with elevation of fetuin-B levels. Conclusion: Circulating fetuin-B levels were significantly increased in PCOS subjects and fetuin-B levels were closely related to cardiovascular risk and hormonal-metabolic disturbances in women with PCOS. OZET Amac :Fetuin-b enerji metabolizmasi, ateroskleroz ve ureme sisteminde rol oynayan yeni bir peptid hormonudur.Polikistik over sendromu (PKOS) ureme ve metabolik sistemleri iceren artmis kardivaskuler risk tasiyan bir hastaliktir.Bu calismada PKOS'lu kadinlarda dolasimdaki Fetuin-b duzeyinde degisiklik olup olmadigini ve Fetuin-b duzeyi ile hormonal-metabolik parametreler ile Karotis intima media kalinligi (CIMT) arasinda bir iliski olup olmadigini tespit etmeyi amacladik. Gerec ve Yontemler:Kesitsel calismamiza 80 PKOS’lu kadin alinmistir. Kontrol grup olarak 80 tane yas ve BMI uyumlu kadin calismaya alinmistir.Dolasimdaki Fetuin-b seviyeleri ELISA yontemi ile olculdu. Ayrica deneklerin metabolik hormonal parametreleri ve CIMT'si de belirlenmistir. Bulgular:Dolasimdaki Fetuin-b duzeyleri PKOS'lu kadinlarda kontrollere gore anlamli derecede yuksek bulundu (409.54 ± 32.51 vs. 325.53 ± 26.86 ng/ml, P<0.001).Insulin direncine sahip PKOS denekleri, insulin direncine sahip olmayan PCOS oznelerine gore anlamli derecede yuksek dolasim Fetuin-B seviyeleri gosterdi (416.03 ± 30.41 vs. 399.27 ± 33.56 ng/ml, P = 0.024). Asiri kilolu / obez kadinlarda PKOS gruplarinda dusuk kilolu deneklerden anlamli derecede daha yuksek dolasimdaki Fetuin-b duzeyleri vardi (416.32 ± 30.99 vs. 400.82 ± 32.77 ng/ml, P = 0.033).Fetuin-B duzeyleri BKI, insulin direncinin homeostaz modelinin degerlendirilmesi (HOMA-IR), free-androgen index (FAI), high sensitivity C-reactive protein (hs-CRP) trigliseritler ve CIMT ile pozitif korelasyon gosterir iken yuksek yogunluklu lipoprotein kolesterol (HDL-C) ile negatif korelasyon gostermektedir. Ayrica ikili lojistik regresyon analizi, PKOS olma riskinin Fetuin-B seviyelerinin yukselmesine paralel olarak arttigini ortaya koydu. Sonuc:Dolasimdaki Fetuin-B duzeyleri PKOS'lu hastalarda anlamli olarak artmis olup Fetuin-B duzeyleri PKOS'lu kadinlarda kardiyovaskuler risk ve hormonal metabolik bozukluklarla yakindan iliskilidir.