Enantiomeric separation of racemic isoflavanones and related compounds on (+)-poly(triphenylmethyl methacrylate)-coated silica gel

(+)-Poly(triphenylmethyl methacrylate)-coated silica gel [Chiralpack OT(+)] was used for the separation of enantiomers of racemic isoflavanone, homoisoflavanone, isoflavan and 2-benzyltetralone derivatives. All the enantiomers of the above-mentioned compounds were separable. The efficiency of the separation depended on both the skeleton and substitution pattern of the racemic compounds. A relation between the number and polarity of substituents in the aromatic rings and the resolution and separation factors was observed.