Phytochemical study of Capraria biflora L. aerial parts (Scrophulariaceae) from Martinique island (French West Indies)

ABSTRACT Aerial parts of Capraria biflora L. were collected in Martinique (French West Indies) and extracted by methanol. Two original chlorinated iridoids, 3-hydroxymyopochlorin ( 1 ) and 5-hydroxyglutinoside ( 2 ) were isolated by CPC (centrifugal partition chromatography) and characterized from the extract together with five known iridoid glycosides ( 3–7 ), two flavonoid glucuronides ( 8–9 ) and the phenylethanoid glycoside verbascoside ( 10 ) . The structure of these compounds together with their relative configuration was established by spectroscopic data including in particular 1D and 2D NMR experiments (HSQC, HMBC, NOESY) and HRESIMS. Preliminary antibacterial evaluation of 1 , 2 and 3 against a panel of Gram-positive and Gram-negative strains has been performed.