A sensitive and high-throughput LC-ESI-MS/MS method to detect budesonide in human plasma: application to an evaluation of pharmacokinetics of budesonide intranasal formulations with and without charcoal-block in healthy volunteers.

Xin Li,Huan Tong,Bing Xu,Yang Deng,Yuan Li,Junchen Huang,Yong Mao,Mengqin Liu,Ping Zhang,Guo Siwei

A sensitive and high-throughput LC-ESI-MS/MS method to detect budesonide in human plasma: application to an evaluation of pharmacokinetics of budesonide intranasal formulations with and without charcoal-block in healthy volunteers.

2021

Xin Li
Huan Tong
Bing Xu
Yang Deng
Yuan Li
Junchen Huang
Yong Mao
Mengqin Liu
Ping Zhang
Guo Siwei

Budesonide is one of the intranasal corticosteroids, referred as first-line therapy for allergic rhinitis. Its determination is a challenging task due to its extremely low plasma levels, which limi...

Keywords:

lc esi ms ms
Chromatography
healthy volunteers
Budesonide
Medicine
Charcoal
Nasal administration
Nasal spray
Pharmacokinetics
Activated charcoal

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