Efficient and green clarithromycin intermediate synthesis process

The invention discloses an efficient and green clarithromycin intermediate synthesis process. Erythrocin A-9-oxime is dissolved in an organic solvent; a strong acid catalyst is used; an etherifying agent is added; reaction is performed for 0.25 to 3h; then, a silanization protecting group and an alkylation catalyst are added; temperature rise is performed for regulating pH; etherification reaction is performed; then, water is added; reaction is terminated; the pH is regulated; water washing layering and concentration are performed to obtain a clarithromycin intermediate compound. The synthesis process has the advantages that the use of alkylation and etherifying agents can be reduced; the reaction time is reduced; the conversation rate is improved; green and environment-friendly effects are achieved; the recovery is easy.