REACTIONS OF K-REGION OXIDES OF CARCINOGENIC AND NONCARCINOGENIC AROMATIC HYDROCARBONS. COMPARATIVE STUDIES ON REACTIONS WITH NUCLEOPHILES AND ACID-CATALYZED REACTIONS

Several K-region arene oxides of carcinogenic and noncarcinogenic polycyclic aromatic hydrocarbons were synthesized, and their reactivities with various nucleophiles and their acid-catalyzed reactions were discussed. Relationship between these chemical reactivities and mutagenicity was also discussed.