Underestimation of 24-hour Hypotensive Efficacy of Nifedipine GITS versus Enalapril: Ambulatory Recording as an Adjunct to Clinical Blood Pressure Measurement

Aims: Short-acting calcium entry blockers should be used primarily in slow-release form. Furthermore, studies of the antihypertensive efficacy of drugs can be negatively influenced by between 15% and 30% of the enrolled patients not being hypertensive according to ambulatory blood pressure (BP) measurement. Thus, a randomized double-blind multicenter parallel-group study was conducted to compare the effect of nifedipine GITS (gastrointestinal therapeutic system) with enalapril. Methods and results