Bordering Zone Hyperemia and Glucose Metabolism in Experimental Cerebral Ischemia

Areas of increased blood flow (hyperemia) at the periphery of ischemic foci have been noted in experimental animals [1]. Experiments using 14C-2-deoxyglucose (2-D G) for the measurement of local cerebral glucose utilization (LCGU) have also demonstrated increased uptake of 2-DG in the bordering zone of focal ischemia [2]. The present study was designed to elucidate the relationship between hyperemia and increased 2-DG uptake in gerbils with unilateral common carotid artery (CCA) occlusion.