Antidiabetic compound and method for producing the same

2001 
The invention provides compounds of the formula (CF DRAWING IN BOPI) wherein A is -O- or -NH-C (O) -; R1 is, for example, (CF DRAWING IN BOPI) (with the conditions that (i) if A is -O-, then n is 2 or 3; (ii) if A is -NH-C (O) -, then n either 1 or 2); R3 is, for example, OH-, CH3 SO2 NH-, CF3 SO2 NH-, CH3 SO2 NHCH2 -, CF3 SO2 NHCH2 -, HOOC-, CH3 OOC-, R 8 OOC-CONH-, HOOC-CH2 SO2 NH-, CF 3 -CH 2 SO 2 NH-, R 8 -NHSO 2 -, R 8 -NHSO 2 -CH 2 -, HOOC-CH 2 -O-, HSO 3 N = CH- or R 9 -SO 2 NHCO-; R4 is H, OH, O-alkyl or O-CH2 OCH3; R5 is H, a halogen atom, -CH2 COOH or OH; R6 and R7 are hydrogen, t-butyl or pyrrolidyl; R8 is hydrogen or lower alkyl; R9 is an alkyl or thienyl group; R10 is a lower alkyl group, and their pharmaceutically acceptable salts, as well as methods for their production. Application to the treatment of diabetes.
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