Comparison of R-ketamine and rapastinel antidepressant effects in the social defeat stress model of depression

Bangkun Yang,Ji-chun Zhang,Mei Han,Wei Yao,Chun Yang,Qian Ren,Min Ma,Qian-xue Chen,Kenji Hashimoto

Comparison of R-ketamine and rapastinel antidepressant effects in the social defeat stress model of depression

2016

Bangkun Yang
Ji-chun Zhang
Mei Han
Wei Yao
Chun Yang
Qian Ren
Min Ma
Qian-xue Chen
Kenji Hashimoto

Rationale The N-methyl-d-aspartate (NMDA) receptor antagonists, including R-ketamine and rapastinel (formerly GLYX-13), show rapid antidepressant effects in animal models of depression.

Keywords:

Psychology
Brain-derived neurotrophic factor
Anesthesia
Social defeat
NMDA receptor
Neuroscience
Antidepressant
Nucleus accumbens
Animal models of depression
Ketamine
Rapastinel

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