Pediatric Protocol LMB is Efficacious in Adult Burkitt's Lymphoma

mg/m 2 day 2, prednisone 60 mg/m 2 /day on days 1-5, methotrexate (+ rescue) 3 g/m 2 day 1 and 15 mg IT day 2. ‡ Sequence 2 and 4 = ara-C 100 mg/m 2 /day on days 1-5, etoposide 150 mg/m 2 /day on days 1-3 Abbreviations: CNS = central nervous system; COP = cyclophosphamide 0.3 g/m 2 on day 1, vincristine 1 mg/m 2 on day 1, and prednisone 60 mg/m 2 /day on day 1; COPAD = cyclophosphamide 500 mg/m 2 days 1-3, vincristine 2 mg days 1 and 6, doxorubicin 60 mg/m 2 day 2, prednisone 60 mg/m 2 /day on days 1-5; COPADM = cyclophosphamide 1000 mg/m 2 /day days 2-4, vincristine 2 mg days 1 and 6, doxorubicin 60 mg/m 2 day 2, prednisone 60 mg/m 2 /day on days 1-5, MTX (+ rescue) 3 g/m 2 day 1, IT MTX 15 mg days 2 and 6, ara-C 40 mg days 2 and 6; CYM = MTX (+ rescue) 3 g/m 2 day 1, ara-C 100 mg/m 2 /day (24-hr infusion) days 2-6, IT MTX 15 mg day 2, IT ara-C 40 mg day 7; CYVE = ara-C 50 mg/m 2 b.i.d days 1-5 (12-hr infusion), ara-C 3 g/m 2 /day days 2-5, etoposide 200 mg/m 2 /day on days 2-5; HD = high dose; IT = intrathecal; MTX = methotrexate