Natural History of Enterovirus Persistence in the Murine Model of Coxsackievirus-Induced Myocarditis: A Quantitative In Situ Hybridization and Immunohistochemistry Study

It is generally accepted that enteroviruses, especially coxsackieviruses of group B (types 1–5), play an important role in acute myocarditis of humans [1]. These RNA viruses, which contain a single-stranded RNA genome of positive polarity can induce dilated cardiomyopathy of acute onset or lead to life-threatening arrhythmias and sudden death.