A Sequence Kernel Association Test for Dichotomous Traits in Family Samples under a Generalized Linear Mixed Model

Qi Yan,Hemant K. Tiwari,Nengjun Yi,Guimin Gao,Kui Zhang,Wan-Yu Lin,Xiang-Yang Lou,Xiangqin Cui,Nianjun Liu

A Sequence Kernel Association Test for Dichotomous Traits in Family Samples under a Generalized Linear Mixed Model

2015

Qi Yan
Hemant K. Tiwari
Nengjun Yi
Guimin Gao
Kui Zhang
Wan-Yu Lin
Xiang-Yang Lou
Xiangqin Cui
Nianjun Liu

Objective: The existing methods for identifying multiple rare variants underlying complex diseases in family samples are underpowered. Therefore, we aim to develo

Keywords:

Statistics
Kernel (linear algebra)
Genetics
Biology
Generalized linear mixed model
association test
data sequences
Computational biology

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