Evaluation of Neuronal Apoptosis Precursors in an Experimental Model of Acute Normovolemic Hemodilution

Fabrício Oliveira Frazílio,Denise Aya Otsuki,J Noel-Morgan,Jessica Ruivo Maximino,Gabriela Pintar de Oliveira,Gerson Chadi,José Otávio Costa Auler,Denise Tabacchi Fantoni

Evaluation of Neuronal Apoptosis Precursors in an Experimental Model of Acute Normovolemic Hemodilution

2014

Fabrício Oliveira Frazílio
Denise Aya Otsuki
J Noel-Morgan
Jessica Ruivo Maximino
Gabriela Pintar de Oliveira
Gerson Chadi
José Otávio Costa Auler
Denise Tabacchi Fantoni

Background The effects of acute anemia on neuronal cells and the safe limits of hematocrit are not well established. The objective of this study was to evaluate neuronal pro- and anti-apoptotic Bax and Bcl-x proteins, caspase-3 and -9 activity, and DNA fragmentation after acute normovolemic hemodilution (ANH).

Keywords:

Caspase 3
Hypoxia (medical)
DNA fragmentation
Anemia
Immunology
Apoptosis
Bcl-2-associated X protein
Hematocrit
Chemistry
Pharmacology
Blood volume

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