Submicroscopic studies on adrenaline secretion from adrenal epinephrocytes

: Some cellular mechanisms governing the secretion of adrenaline by epinephrocytes of guinea pigs sacrificed because of acute anaphylaxis produced by inhalatory administration of ovoalbumin following sensitization with this antigen have been studied. In acute anaphylaxis the adrenaline secretion from epinephrocytes occurs mainly by massive and facilitated exocytosis mechanism that differs from the classical exocytosis one. Increase in the concentration of ionized calcium, increase in the number of microtubules, and decrease in the number of microfilaments in the epinephrocytes have the essential significance in the mechanism of this secretion.