Metabolomic profile in HFpEF vs HFrEF patients.

ABSTRACT BACKGROUND HFpEF and HFrEF are associated with metabolic derangements which may have different pathophysiological implications. METHODS AND RESULTS In new onset heart failure with preserved (HFpEF;EF≥50%,n=46) and reduced ejection fraction (HFrEF;EF CONCLUSIONS New onset HFpEF compared to HFrEF patients display a different metabolic profile associated with co-morbidities such as diabetes and kidney dysfunction. HFpEF is associated with indices of increased inflammation and oxidative stress, impaired lipid metabolism, increased collagen synthesis and down-regulated NO-signalling. Together, these findings suggest a more predominant systemic microvascular endothelial dysfunction and inflammation linked to increased fibrosis in HFpEF compared to HFrEF. Clinical Trial Registration: ClinicalTrials.gov NCT03671122 https://clinicaltrials.gov