Cultivation and modification of infectious canine hepatitis virus in roller tube cultures of dog kidney.
1954
Summary1. Propagation of ICH virus with the production of distinctive cytologic changes has been demonstrated in roller tube cultures of dog kidney. 2. After 51 serial passages the virus apparently had lost its virulence for dogs, although producing a solid immunity. 3. A practical neutralization test for the diagnosis of ICH has been described.
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