Carbonic Anhydrase IV Inhibits Colon Cancer Development by Inhibiting WNT Signaling Pathway Through Targeting WTAP-WT1-TBL1 Axis

Caustic ingestion, whether accidental or intentional, causes severe injury to the esophagus and the stomach and may be associated with significant morbidity and even mortality. Several factors have been identified as possible predictors for these outcomes. This retrospective, crosssectional study which included 303 adult cases of caustic ingestion showed that surgery rate (19.2%) andmortality rate (8.1%) in cases of caustic ingestion admitted in our institution are similar to published data from other countries. Age, gender, nature and volume of ingested substance, intent of ingestion, presence of symptoms, other medical comorbidities (hypertension, diabetes mellitus, etc.), severity of mucosal injury based on Zargar score, and leukocytosis were not associated with mortality. Presence of metabolic acidosis upon admission (P 1⁄4 .001), psychiatric disorder, need for surgery (P .001), and perforation (P .001) were significantly different between patients who expired and who survived from admission of caustic ingestion. Metabolic acidosis (OR 10.6, 95%CI 2.17, 76, P1⁄4 .006), need for surgery (OR 13.3, 95%CI3.9, 44.6,< .001), andperforation (OR22.2, 95%CI 8.3, 70.4, P 0.001), were associated with risk of mortality. Institution of surgical management showed the most consistent and strongest association with mortality (adjustedOR23.2, 95%CI 2.96, 496.74,P1⁄4 .008) based on multivariable regression analysis.