Synthesis and antimicrobial activity of 5-(2-aminothiazol-4-yl)-3, 4-dihydro-4-phenyl pyrimidin-2(1 H )-one

A series of hybrid 5-(2-aminothiazol-4-yl)-3,4-dihydro-4-phenyl pyrimidin-2(1H)-ones (ATDPP) are reported. Efficient cyclocondensation of appropriately substituted 5-(2-bromoacetyl)-3,4-dihydro-4-phenylpyrimidine-2(1H)-ones (BADPP) with thiourea in ethanol proceeds in high yield to furnish the corresponding ATDPPs. Dihydropyrimidine carboxylates (DHPMS) and their bromo derivatives are the key substrates for cyclocondensation. The ATDPPS revealed biological activity as antimicrobial and antifungal agents against S. aureus, P. aurogenosa, K. pneumonae and C. albicans.